7,8-DIHYDROXYFLAVONE Yellow powder TIMTEC-BB SBB000930 Lowering blood pressure
7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone
found in Godmania aesculifolia, Tridax procumbens, and primula tree
leaves. It has been found to act as a potent and selective
small-moleculeagonist of the TrkB receptor (Kd ≈ 320 nM), the main
signaling receptor of brain-derived neurotrophic
factor(BDNF).7,8-DHF is both orally-bioavailable and able to
penetrate the blood-brain-barrier.
7,8-Dihydroxyflavone is disubstituted flavone that acts as a
small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to
reverse memory deficits and BACE1 elevation in a mouse model of
Alzheim er's disease. 7,8-Dihydroxyflavone may also provide a
therapeutic option in the treatment of other neorological disorders
such as Rett syndrome and PTSD.
|Product Categories:||Di-substituted Flavones;Biochemistry;Flavonoids;Inhibitors|
|storage temp.||Store at +4°C|
|CAS DataBase Reference||38183-03-8(CAS DataBase Reference)|
|Chemical Properties||Yellow Solid|
|Biological Activity||Tyrosine kinase receptor B (TrkB) agonist that binds to the
extracellular domain of the receptor (K d = 320 nM). Inhibits
glutamate-triggered apoptosis in hippocampal neurons in vitro and
in vivo .|
Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in
Jiayu, Hubei, and produce small quantity and customer synthesis
products in our lab located in Wuhan.
Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep
stock for most products. However, for some rare products, we won't
keep stock and it needs time to synthesize.
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC,
Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled &
fully experienced staff, working in chemical industry for over 5
years, in average.
Strict quality control-comes form our sophisticated management
Professional and warm sales team-since we believe we can only win
via our hard work in a competitive world
Quick response and excellent presale and after sale service-since
we believe our customers deserve all the best service
Q5: Can I get best price from you?
A: Of course. We don't chase excessive profits and always try tp
give best offer. If you are good at bargaining, you can also enjoy
fun of bargaining. Just don't make it too hard!
Q6: How should I pay?
A: We accept all kinds of payment ways. such as alibaba trade
asssurance, T/T, West union, Paypal.
Q7: Do you provide free sample?
A: Yes, we can provide free sample if we have in stock, just need
you to cover the delivery cost.